The most important thing is to have a targeting effect on the virus, and the only targeting effect is the antibodies, the main antibodies are IgG and IgA, and the vaccine is administered to produce IgG. So for many years, the most effective against the virus is the vaccine, to reduce the replication of the virus, the most important thing is to block the virus from entering the cell.
There are 2 ways to block the virus from entering cells
- The immune system recognizes that the virus has invaded and activates a series of immune responses early.
- Blocking from the infection route. Almost all viruses can only infect humans or animals from the mucosa, and the largest route of infection is the mucosa of the respiratory tract and the mucosa of the digestive tract. Mucosal immunity is characterized by systemic immune protection. The anti-body IgA produced by mucosal immunity will neutralize the virus in the blood, while the vast majority will circulate with the blood to the mucous membranes throughout the body in the form of S-IgA, which neutralizes the virus on the surface of the mucous membranes and prevents the virus from entering the body and causing infection.
The presence of viruses in our mouth and nasal passages means that viruses do enter the body through the mouth and nose. Mucosal immunity allows the immune system to quickly recognize viruses and activate protection, keeping them out of the mucosa and preventing them from entering the body and causing infection. IgA is produced by intestinal mucosal immunity, and IgA neutralizes environmental wild viruses in large quantities in the mucosal layer, so that environmental wild viruses do not invade rapidly and in large quantities, giving the immune system time to react and clear the viruses already in the body. The environmental mutation of the virus continuously allows the intestinal mucosa to recognize the mutated virus and produce the corresponding antibodies IgA to neutralize the virus in the mucosal surface.
Most of the B cells and T cells are in the intestine, which is why the intestine is the largest immune organ, and in response to the variability of viruses, vaccines have lost their targetability, resulting in the continuous spread of viruses. The IgA produced by mucosal immunity will be the main force in the fight against viruses in the next century.
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